Why Do Scientists Need Primary Cells ?
Primary cells refer to cells that are straightly taken from human and animal tissue with no passages, typically used as biologically relevant and in-vivo cell model. These cells can provide extremely accurate information and more relevant results than cell lines in research. They serve as ideal cell models for a vast variety of research, from fundamental cell biology and physiology, developmental biology, disease mechanisms, to drug screening and therapeutics development.
Though primary cells are replaced by immortalized cell lines in some occasions, they still remain the most ideal choice to meet the increasing need for more relevant and more accurate models. The most physiologically relevant systems are the best models for experimentation, studying disease, and identification of therapeutic targets and drugs specific for those targets. This explains why primary cells can not be completely replaced by cell lines in the laboratory.
However, primary cells are more than just a sound cell model in the laboratory. The advantages are particularly clear when studying diseases such as cancer, diabetes, diseases involving the skin, bone marrow and liver.
Primary cells are very essential for cancer research. They are used to confirm the validity of the results obtained from cell lines, predict the response and resistance based on individual patient primary samples and select the most likely drug candidates. They are also used to test for the most selective/toxic compounds against the tumor, identify new drug targets and validate new drugs.
Primary cells from different species allow for highlighting potential differences between humans and preclinical test species. Before in vivo studies rats or mouse cells can be used to refine doses and reduce the number of animals required for preclinical toxicology. Human primary cells can be used to determine accuracy of extrapolating human data from an animal model. For example, human keratinocytes has been used for skin diseases, toxicology testing for cosmetics. What’s more, the use of primary cells is also extending to researches on bone marrow, bone development and diabetes.
Creative Bioarray, as one of the world’s leading cell products supplier, produces the world’s most comprehensive list of research-use cells, including tumor cells, primary cells, stem cells and transformed cells.We offer 35 human cell systems with over 160 different cell types and also provide primary cells from over 13 types of animals. These cells taken from living tissue are extremely accurate as they are literally coming from the sources.These living samples can give extremely accurate information about the cells in vivo and give relevant information regarding the living systems.
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